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KMID : 1146920180480030243
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Journal of Pharmaceutical Investigation
2018 Volume.48 No. 3 p.243 ~ p.250
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Enhanced topical delivery of fish scale collagen employing negatively surface-modified nanoliposome
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Seo Jo-Eun
Kim Min-Ju
Jeon Sang-Ok
Oh Dong-Ho
Yoon Kyu-Hyung
Choi Young-Wook
Bashyal Santosh
Lee Sang-Kil
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Abstract
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In this study, we investigated the effect of fish scale collage (FSC) on type I procollagen expression in cultured human dermal fibroblasts using real-time polymerase chain reaction and ELISA, under normal and UV exposure condition. Also, FSC encapsulated negatively surface modified nanoliposome (NLsurf mod) was fabricated, and the physicochemical characteristics of the liposomes and skin permeation properties were evaluated. FSC increased type I procollagen mRNA and protein expression in human dermal fibroblasts. The mean particle size, zeta potential value and encapsulation efficiency of the NLsurf mod were about 175 nm, ?44 mV and 11%, respectively. The skin localization effect was enhanced by NLsurf mod. Conclusively, FSC is able to elevate the type I procollagen expression in human dermal fibroblasts and FSC-loaded NLsurf mod would be a good candidate for the topical delivery of FSC.
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KEYWORD
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Fish scale collagen (FSC), Nanoliposome, Surface modification, Topical drug delivery
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